The history of cardiovascular disease research in the USA is long, complicated, and mostly honorable. Many of the greatest names and accomplishments in American biomedical research are in this field. This history should not be simplified by Ms. Streisand's well-intentioned statements concerning the paucity of research into specifically women's cardiovascular health issues. Originally, there were reasons for the study of males instead of females. It was recognized early on that the female hormonal changes occurring over the monthly cycle and into the menopausal state complicated study of the basic mechanisms underlying the advent and progression of cardiovascular disease. Most studies into basic mechanisms over the last 70 years used male animals to eliminate the female hormonal effects. The same may be true for human research; when many of the early clinical trials were initiated, men made up the vast majority of patients with recognized and symptomatic cardiovascular disease. I don't believe there was a systematic and nefarious attempt by the "boy's club" to avoid the study of women's health issues. This is being corrected as the study of cardiovascular disease evolves.